Allyson Kazmucha
How-to, jailbreak, and DIY Editor at iMore, owner at The Pod Drop & AnoStyle, Potter pundit, and the ninja in your iOS
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Source: http://www.imore.com/how-download-photos-dropbox-directly-your-iphone-or-ipad-camera-roll
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By Peter Apps, Political Risk Correspondent
WASHINGTON (Reuters) - Striking Islamist militants with drones, supporting African forces in stabilizing Somalia and Mali and deploying dozens of training teams, the U.S. military has returned to Africa.
Its presence remains mostly low key, barely mentioned in the context of President Barack Obama's visit this week to Africa.
Nevertheless, with some 4,000-5,000 personnel on the ground at any given time, the United States now has more troops in Africa than at any point since its Somalia intervention two decades ago. That ended in humiliation and withdrawal after the 1993 "Blackhawk Down" debacle in which 18 U.S. soldiers died.
There are two main reasons behind the build up: to counter al Qaeda and other militant groups, and to win influence in a continent that could become an increasingly important destination for American trade and investment as China's presence grows in Africa.
Obama's eight-day trip is heavily focused not on military issues but on trade and economic development in visits to Senegal, South Africa and Tanzania.
In the Horn of Africa, the vast majority of U.S. forces deployed in Africa are at a major French military base in Djibouti, a tiny country sandwiched between northern Somalia, Ethiopia and Eritrea.
While U.S. officials will not comment in detail on what happens at the base, experts say it has provided a staging post for occasional special forces deployments and drone and air attacks against Islamist militant targets in Somalia.
Dramatic as those actions are, smaller U.S. operations and outreach programs often with only a handful of troops are key to the strategy of winning influence in a continent where China has surpassed the United States as the No.1 trade partner and has huge mining, energy and infrastructure investments.
Such limited missions, U.S. officers say, have gone a long way to reducing initial African skepticism over Germany-based AFRICOM, set up in 2008 to bring all U.S. military activity in Africa under one unified command, rather than dividing responsibility between commanders in Europe, the Middle East and Asia.
"We are focusing on building human capital," says Major General Charles Hooper, head of strategy and plans at AFRICOM. "The smaller missions can be some of the most effective when it comes to gaining trust."
In Angola, Namibia, Democratic Republic of Congo and elsewhere, U.S. engineers have helped train local counterparts in landmine clearance. In southern Africa, military medics have helped local armies tackle HIV infection while in Mauritania, the focus has been on veterinary aid to local ranchers.
U.S. warships combating piracy off both East and West Africa are increasingly frequent visitors to local ports.
One U.S. aim is to convince African militaries their interests are best served by remaining democratically accountable and not interfering in politics.
Some operations, however, have hit just that problem. The hunt in Central African Republic for Ugandan warlord and head of the rebel Lord's Resistance Army Joseph Kony has largely been suspended following a March coup in CAR.
The anti-LRA mission had been the only one in Africa in which combat troops were deployed, involving just over 100 U.S. special forces personnel. U.S. forces continue to train Ugandan and other armies as part of that operation.
KICKED OUT OF MOROCCO, ACTIVE IN SOMALIA
Critics in Africa complain Washington's approach to the continent has become increasingly militarized and focused on counterterrorism. Others worry U.S. military clout may ultimately be used to seize resources.
Administration officials disagree and point to Obama's visit as evidence of U.S. intentions.
"This trip ultimately disproves the notion that we're somehow securitizing the relationship with Africa," Deputy National Security Adviser Ben Rhodes told a conference call last week. "This trip is expressly devoted to trade and investment, democratic institution-building, young people and unleashing economic growth through some of our development priority."
In general, U.S. forces have only been able to operate when African governments - or sometimes France, which maintains a network of bases in former colonies - allow them to.
Permission can be quickly withdrawn for political reasons.
In April, Morocco canceled its annual Exercise African Lion with U.S. forces after a suggestion from Washington that U.N. monitors in the disputed Western Sahara region should extend their mandate to include human rights.
The United States still treads carefully in Somalia, the scene of a serious reverse in 1993 when militia fighters killed 18 Americans on a mission to capture a Somali warlord in support of a U.N. mission.
U.S. officials say there are often one or two U.S. liaison officers deployed inside Somalia helping African Union forces fight Islamist group al Shabaab - which is linked to al Qaeda - on behalf of Somalia's transitional government.
Most of the U.S. support for the African Union mission AMISOM remains outside the country, training forces in Kenya, Uganda and elsewhere.
It is a similar picture on the other side of the continent, where the U.S. military is also acting primarily in support of local nations and France.
The aftermath of the 2011 Libya war has seen a flood of weapons and militants across the Sahel, fueling the rise of al Qaeda in the Islamic Maghreb which briefly captured much of northern Mali before a French offensive there earlier this year.
The U.S. Air Force provided much of the transport for both African and French reinforcements in Mali, while U.S. air tankers from RAF Mildenhall in England have flown long missions over the Sahara refueling French combat jets.
Some 100 U.S. personnel deployed to Niger to set up a drone base. Unlike in East Africa, however, the drones will be unarmed and used only for reconnaissance to track Islamist militants.
U.S. and African officials say Washington has long been reluctant to share its most sophisticated intelligence with African partners, in part over worries it might fall into the wrong hands.
African officers say that if they are to be truly effective at fighting militants in their own countries and as part of broader Mali-type missions, they need to know as much as possible about rebel movements, locations and plans.
"The Americans are our friends - but often they are friends who are not frank," says former Senegalese army chief Mansour Seck, also an ex-ambassador to Washington. "They have a tendency to ask you what you have but will not tell you what they have."
Source: http://news.yahoo.com/multiple-missions-us-military-steps-africa-focus-063132636.html
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For decades, computer owners have been forced to unplug their desktops, transport their computer to a local computer repair shop, and from there wait for days, weeks, and sometimes a month or more for their computer to be fixed. Often times being forced to pay high rates for?computer services, users have also placed their data, personal information, and more in the hands of the experts at these computer repair locations. There are too many negatives associated with this method of fixing computers, yet this has been the ?norm? for as long as the personal computer has been prevalent.
That is, until now. Online Virus Repair Inc. is pleased to announce a?new method?that allows anyone with viruses, spyware, adware, and other types of malware, to quickly have their computer cleaned up, without the need to leave the comfort of their home or office chair. By connecting remotely to a US-based computer repair professional, those infected with the nastiest infections the Internet has to offer can take solace in knowing that the individual on the other end can completely remove the bad stuff, generally in under an hour. Moreover, because a professional on the other end is controlling the victim?s computer remotely, they can also take solace in knowing exactly what the technician is viewing on their computer at all times. The new method saves a great deal of time, and costs significantly less than most local computer shops.
?We depend on our computers and technology now, more than ever,? says Dan Steiner, President of Online Virus Repair Inc., ?When a virus hits, it can be a disaster. Our new service allows computer users from around the nation to quickly connect with one of our experts in a minute, without the need to unplug anything.? The new service has proven to be highly effective against even the trickiest viruses out there, including modern ransomware and rootkit viruses that often make computers unusable.
Steiner continues to say ?We?ve built our service to be as hassle-free as possible. We have no pushy sales reps, annoying phone systems, or funky contracts. People can immediately connect with a trained expert, get a free checkup, and if needed, use one of our services to resolve any issues.?
About Online Virus Repair Inc.
Online Virus Repair Inc.?is an American based company specializing in online virus removal for individual computer users and businesses. The company was founded in 2012 and is headquartered in San Luis Obispo, CA. Customers with infected machines can call or chat with OnlineVirusRepair.com technicians to have viruses/malware/spyware removed remotely, without the hassle of taking their computer ?into the shop.? Technicians are able to remotely remove threats even without the client being at their computer, often in 60 minutes or less.
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TOKYO (Reuters) - One of All Nippon Airways' 787 Dreamliner jets, made by Boeing Co, had a cockpit message saying that the aircraft might not be able to supply power for its air-conditioning system, the Japanese airline said on Thursday.
The issue was not related to the lithium ion battery problems that had grounded the jets for three months from mid-January, Ryosei Nomura, an ANA spokesman, said.
All Dreamliner jets are under the microscope after Boeing installed a re-designed battery system and they resumed flying. Last week, two United Airlines Dreamliner jets were diverted due to separate oil-related problems.
More than 100 passengers who were supposed to fly on the ANA jet from Tokyo to Frankfurt on Thursday ended up taking a different plane that departed nearly eight hours later than originally scheduled, Nomura said.
ANA fixed the problem by exchanging components of a computer that controls electricity supply to the air-conditioning system, said Shinsuke Satake, another company spokesman.
(Reporting by Yoko Kubota; editing by Jane Baird)
Source: http://news.yahoo.com/ana-says-dreamliner-jet-had-problem-ac-power-105803047.html
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(Adds details, background)
QUITO, June 27 (Reuters) - Ecuador said on Thursday it was waiving preferential rights under a U.S. trade agreement to demonstrate its principled approach to the asylum request of former American spy agency contractor Edward Snowden.
Officials in Quito added that the U.S. fugitive's case had still not been processed because he had not reached any of its diplomatic premises.
In a deliberately cheeky touch from the leftist government of President Rafael Correa, Ecuador also offered a multimillion donation for human rights training in the United States.
Snowden, 30, is believed to be at Moscow's international airport.
"The petitioner is not in Ecuadorean territory as the law requires," government official Betty Tola said at an early morning news conference in Ecuador.
Bristling at suggestions Quito was weighing the pros and cons of Snowden's case in terms of its own interests, officials also said Ecuador would not base its decision on its desire to renew the Andean Trade Preferences Act with Washington.
"Ecuador gives up, unilaterally and irrevocably, the said customs benefits," said another official, Fernando Alvarado.
"What's more, Ecuador offers the United States economic aid of $23 million annually, similar to what we received with the trade benefits, with the intention of providing education about human rights," Alvarado added.
"Ecuador does not accept pressure or threats from anyone, nor does it trade with principles or submit them to mercantile interests, however important those may be." (Reporting by Brian Ellsworth and Alexandra Valencia; Writing by Andrew Cawthorne; Editing by Doina Chiacu)
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Batman had one under his mansion outside Gotham. Osama bin Laden was found in one just in Pakistan. Underground lairs are an integral part of pop culture fantasy and real-life current events?but whether they're fake or real, they're always cloaked in intrigue. And frankly, they're cool as hell.
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June 26, 2013 ? Proposed method could be more efficient than previous systems and easier to retrofit in existing power plants.
Many researchers around the world are seeking ways to "scrub" carbon dioxide (CO2) from the emissions of fossil-fuel power plants as a way of curbing the gas that is considered most responsible for global climate change. But most such systems rely on complex plumbing to divert the steam used to drive the turbines that generate power in these plants, and such systems are not practical as retrofits to existing plants.
Now, researchers at MIT have come up with a scrubbing system that requires no steam connection, can operate at lower temperatures, and would essentially be a "plug-and-play" solution that could be added relatively easily to any existing power plant.
The new electrochemical system is described in a paper just published online in the journal Energy and Environmental Science, and written by doctoral student Michael Stern, chemical engineering professor T. Alan Hatton and two others.
The system is a variation on a well-studied technology that uses chemical compounds called amines, which bind with CO2 in the plant's emission stream and can then release the gas when heated in a separate chamber. But the conventional process requires that almost half of the power plant's low-pressure steam be diverted to provide the heat needed to force the amines to release the gas. That massive diversion would require such extensive changes to existing power plants that it is not considered economically feasible as a retrofit.
In the new system, an electrochemical process replaces the steam-based separation of amines and CO2. This system only requires electricity, so it can easily be added to an existing plant.
The system uses a solution of amines, injected at the top of an absorption column in which the effluent gases are rising from below. The amines bind with CO2 in the emissions stream and are collected in liquid form at the bottom of the column. Then, they are processed electrochemically, using a metal electrode to force the release of the CO2; the original amine molecules are then regenerated and reused.
As with the conventional thermal-amine scrubber systems, this technology should be capable of removing 90 percent of CO2 from a plant's emissions, the researchers say. But while the conventional CO2-capture process uses about 40 percent of a plant's power output, the new system would consume only about 25 percent of the power, making it more attractive.
In addition, while steam-based systems must operate continuously, the all-electric system can be dialed back during peak demand, providing greater operational flexibility, Stern says. "Our system is something you just plug in, so you can quickly turn it down when you have a high cost or high need for electricity," he says.
Another advantage is that this process produces CO2 under pressure, which is required to inject the gas into underground reservoirs for long-term disposal. Other systems require a separate compressor to pressurize the gas, creating further complexity and inefficiency.
The chemicals themselves -- mostly small polyamines -- are widely used and easily available industrial materials, says Hatton, the Ralph Landau Professor of Chemical Engineering Practice. Further research will examine which of several such compounds works best in the proposed system.
So far, the research team, which also includes former MIT research scientist Fritz Simeon and Howard Herzog, a senior research engineer at the MIT Energy Initiative, has done mathematical modeling and a small-scale laboratory test of the system. Next, they hope to move on to larger-scale tests to prove the system's performance. They say it could take five to 10 years for the system to be developed to the point of widespread commercialization.
Because it does not rely on steam from a boiler, this system could also be used for other applications that do not involve steam -- such as cement factories, which are among the leading producers of CO2 emissions, Stern says. It could also be used to curb emissions from steel or aluminum plants.
It could also be useful in other CO2 removal, Hatton says, such as in submarines or spacecraft, where carbon dioxide can accumulate to levels that could endanger human health, and must be continually removed.
The work was supported by Siemens AG and by the U.S. Department of Energy through the Advanced Research Projects Agency for Energy.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/8uT9pW8An2g/130626143110.htm
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Pioneer's new SB-PS23W is a soundbar the way most people want it: A simple, relatively inexpensive way to make a television sound louder. In that way, it's cut from the same cloth as the fantastic AirPlay speakers
From what we just heard this $400 soundbar has a lot of the same potential for the basic soundbar market. The six-speaker array sits in a a handsome wooden enclosure that's larger than most. While that might not necessarily mesh with the "invisible" aesthetic most soundbars are going for, it gives the music some space to resonate. (The included wireless sub helps fill out the bottom-end nicely as well.) The sound of sweet guitars resonating in wood?just the way it should be.
How do movies sound? Well, see now, that's the thing?Pioneer wasn't demoing movies because the system is designed for stereo. That means you're not getting any fancy surround sound emulation. Pioneer reps said we're "three years away" from being able to do surround sound well from a soundbar. That's definitely not true, but at a $300 price point?surrrrre.
But the trade of of is simplicity and price. This new sound bar only takes two inputs?optical digital and RCA. So you'll need a separate hub?a TV will do!?to handle all your HDMI inputs.
Usual first impression disclaimer applies: I listened to this thing for a few minutes only, so we'll have to wait and see how it holds up against the cheap soundbars we reviewed last year.
Source: http://gizmodo.com/pioneers-new-soundbar-is-beautifully-simple-and-wonder-585654401
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Price: $359 for saw only; $647 for saw, charger, and two batteries.
Gas-powered chain saws are the right tool for big jobs such as felling trees or carving up logs larger than 6 or 8 inches in diameter. But a cordless electric model is the way to go for brushing and slashing?cutting up trees and branches under 6 inches in diameter.
Recently I found myself facing four piles of debris fitting this description in my yard, and I got down to business with the Makita X2 LXT Lithium-Ion Cordless Chainsaw. Twin 18-volt batteries powered a quiet motor that presented no danger of annoying my neighbors or damaging my hearing. While gas-powered saws can scream louder than 110 decibels, the Makita generates just 89, but still produces cutting power of 1650 fpm, or surface feet per minute. That?s significantly less than many gas-powered saws but sufficient for the job I faced. With both batteries fully charged, I was able to work steadily for 90 minutes, reducing the debris piles to small stacks of logs and branches ready to be bundled.
Likes: Weighing in at just more than10 pounds, including the batteries, the saw was easy to maneuver and arm-fatigue was not a factor. The chain-tensioning device is a user-friendly dial beneath a little hatch on the body of the saw. Anyone who has ever had to tighten the chain on a typical gas-powered chain saw can appreciate the convenience of not having to use a socket wrench and screwdriver combo tool for this task. The Makita?s cuts were clean and the saw was steady in the hands with minimal kickback.
Dislikes: Since the saw is so light and easy to manipulate, I found myself getting a little reckless and fast in my work. I had to slow down and remind myself that all chain saws, including this very efficient cordless electric, can cause serious harm in a split second. Also, while the charger is fast?30 minutes to top off an empty battery?it had just one port, so the effective recharging time for the entire saw is 60 minutes.
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John Hodgman is the world's foremost expert on all things canny and uncanny
Last year, Hodgman did a comedy show about the apocalypse, timed to the supposed end of the world on December 21. And now it's available via Netflix, as of today. We talked to Hodgman on the phone for 20 minutes, and he told us all about the end of everything.
Where did the idea for doing an apocalypse-themed stand up tour and comedy special come from?
Well, I?m afraid of death. I?m unusual in that, I think. I turned forty a couple of years ago, and that is when a lot of humans start to really contemplate their mortality. Up until then it is pretty easy to pretend you are immortal, but when you turn forty it starts to come into focus that you are not beginning something but ending something and to think about what that ending is. Then I realized we were in the midst of this apocalyptic fervor surrounding the whole new age theory of the Mayan long-count calendar somehow encoding the end of the world or the end of some major period of human history.
And you know, apocalyptic visions are stories and books of the Bible and movies, and so on, are comforting ? even though they involve the death of millions of people ? because A) they usually involve one survivor or include in their story the idea that you are going to be the one who is going to be lifted up to Heaven or get to wander through the streets of empty New York or survive the zombie plague and finally get to shoot your former neighbors in the head. You know what I mean? So those are all kind of wish fulfillment.
And B) even if you imagine that you are not going to survive, there is something comforting in so far as? It's not merely that you die, it?s that when you die, you get take the whole world out with you in that apocalyptic situation. Your passing is noted with the passing of all civilization and life on Earth. That, in a dark way, is comforting because the alternative is, what is actually frankly true for most people: That your death will pass relatively unnoticed and over time will not be remembered at all.
There is a picture of H.P. Lovecraft on the set of the special. The thing that I think he understood ? the thing about horror ? is not merely the horror of the unknown, but the horror of your own insignificance. And that the Old Ones and the pan-dimensional monster creatures that inhabit the margins of his stories, what makes them terrifying is not just the tentacles, but the fact they predate human history by millennia and will post date human history by even more millennia. The idea that we are as cosmically insignificant as we are is terrifying. That?s all. That?s the most terrifying.
What?s your favorite type of apocalypse? Zombies, asteroids, plagues?
What apocalypse do I find most comfortable? Well, zombies ? I?m not as into [zombies] as the rest of the world is. Because I think, as I say, that the wish fulfillment fantasy there is pretty transparent and juvenile ? which is [that] you get to hurt people with impunity, in a world where laws no longer apply to you. And, you know your perverse desire to murder is justified entirely, because you are constantly in a kill-or-be-killed situation. There is no nuance to the zombies. They want only brains and they cannot be reasoned with, and therefore there is nothing you can do. You?ve got to just go on a murderous rampage yourself.
But I guess probably the one I find most [compelling] is the "last person on Earth" scenario. Because there is that element of getting to drive through the abandoned city at high speeds and get to wander into every [apartment]. You know I live in New York City, so 40% of my brain is filled with apartment and lifestyle envy, so getting to wander through all the different lives that used to inhabit there [is an attractive fantasy]. But I also find that it is appropriately discomforting as well, because what is worse than death? Being the last person on earth. That is the loneliness we are all going to face in our personal apocalypse.
A lot of my quote-unquote "research" for thinking about the apocalypse was reading Stephen King?s The Stand. And not just the short version either. The whole directors cut, that he put out once he got his money together. So I had never read it when I was younger. I read it for the first time, I?m embarrassed to admit, over the past couple of years ago, when I was starting to think about this material. I found it very compelling and relatively timeless. And chilling.
Do you think the apocalypse should be religious or secular?
I am a true agnostic, which as you know is the lazy person's atheism. Kind of don't want to take a side. And truly, I think that even though my dark instincts are that there is nothing beyond ? and I am willing to say that there is little to no compelling evidence that there is something beyond ? I am always the first to announce my ignorance, and willingness to accept there might be evidence that I haven't gotten yet. That may be just grasping for hope. The reality is that I just don't know. And the apocalypses, such as the Book of Revelation, have less purchase on my imagination, because it seems more likely that we will not be Raptured to a special place.
And [a story that has] far less blood and fury, and [is] far more terrifying, of course, is The Road, which s a totally compelling and realistic and fatalistic imagination of what would happen if society went away. The thing about that book was, it was unbearable to read. To the point of getting mad ? like, why would you put someone through this? And then you kind of experience what it would be like to go through something like that, in the sense that your sensibilities get callused over, your emotions get callused, as they would have to in any profoundly traumatic experience where you see something that you hope never to have seen. And you become caught up in going forward through the book, just as the guy gets caught up in going forward down the road, even though you as the reader, and he as the protagonist, know just how hopeless the whole exercise is. There is something profoundly true about the human dumb persistence in life that is given real relief if you do not believe in an afterlife.
That just got real deep, right?
But then I realized I hadn't really checked in with the biography of Cormac McCarthy in a long time. And he had kind of come out of seclusion to do some press for the movie of The Road when that came out. So there were some more recent interviews with him. So the story that he [shared] was, "I started thinking about The Road when I was on a trip through Ireland with my son, a couple of years ago, who was about the same age at the time [as the boy in the novel.]" And I was like, "Wait a minute. You have a twelve-year-old son, Cormac McCarthy? What's your age again? Oh yeah. You're 79, or whatever. Oh, you're a guy who had a son very late in life. You are not writing about the human condition, or a global apocalypse, you're writing about the personal apocalypse that you're facing. You realize that you're not going to see your son grow up." So I got mad at Cormac McCarthy for putting me through all that, when it turns out he was just working through his own dumb emotions. [Laughs]
I'm not really mad at Cormac McCarthy, but that book really did a number on me.
Has the apocalypse gotten more literary in the last decade? It used to be a lot more goofy, like in the days of Mad Max and Hell Comes to Frogtown.
Yeah, I miss those days. There's some really, really interesting [stuff happening now]. It was an interesting thing that happened when Cormac McCarthy wrote essentially a science fiction novel. Without any science in it. But a speculative fiction novel about a future apocalypse. And there's beautiful and moving and powerful and literary speculative fiction out there that is not ashamed of the genre. And I'm not suggesting that Cormac McCarthy was ? but the way that book was treated by most humans in the world was, "Finally someone has done a serious book [of speculative fiction.]"
And I was like, "That's not true." The fact that that book was treated better than other great works along the same theme ? including, for that matter, The Stand. Line by line, it's hard to find a better writer than Stephen King. This guy is up there. While it takes its own melodramatic turns, there are moments of abject sorrow and terror in there that rival anything I've read under the "literary" umbrella. And as human and as revelatory.
There is a general fascination, that maybe has come to its head or maybe is still going on, with this feeling that things ? particularly American culture and American primacy ? [are] kind of unraveling. And there is an anxiety, that is appropriate to the times, that we have done such damage to this planet that it may be irreversible. So there is an apocalyptic mood in general, culturally and politically, that is getting everyone's attention from the far-right doomsday preppers, who are underground and imagine the New World Order is coming... to the Chardonnay club of literary circles in New York, who read and discussed The Road.
But certainly, I think the success of that book and the acclaim it got opened the door for writers who might not necessarily have taken a look at these kinds of [topics, and] might not have felt comfortable working in genre before.
Are you going to see World War Z?
Sure. Only because I have to. As much as I malign the zombie thing, what Max Brooks did was more interesting than mass-murder wish fulfillment, so I'm definitely going to check it out.
People talk about the Soft Apocalypse, where everything is just super gradual. What would be the softest apocalypse?
Every day, as we're living it today. It's hard not to feel like frogs in a gently simmering pan at the moment. The softest apocalypse is the one we're living right now, and the one that we face every minute that passes, before the individual apocalypse that awaits the end of all of our days.
Thanks to Amanda Yesilbas for transcription.
Source: http://io9.com/john-hodgman-explains-the-end-of-the-world-to-you-521452635
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Charlie Rose
In a 2010 interview with the Los Angeles Times, Karp said, "We're pretty opposed to advertising. It really turns our stomachs."
Although he admitted some defeat while announcing ?Tumblr's very first ad units in April 2012 ??"I was probably being an idiot then," Karp said ? he has done a complete 180 since selling the social platform to a very ad-friendly Yahoo for $1.1 billion.
Advertisers' biggest and swankiest festival, the Cannes Lions, is taking place this week, and Karp is there wooing potential partners.
Ad Age reports, "Words like "humbled," "privileged," and "honored" tripped off his tongue, as did the hope that next year the crowd would be winning Lions for work created on Tumblr."
Karp also stated to the audience, "You guys are more talented than any one in the Tumblr office or in Palo Alto or Sunnyvale. We're constantly in awe, constantly in service."
Oh how the times have changed.
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June 19, 2013 ? Two clinical studies published in the New England Journal of Medicine with an accompanying editorial suggest that the novel agent ibrutinib shows real potential as a safe, effective, targeted treatment for adults with chronic lymphocytic leukemia (CLL) and for patients with mantle cell lymphoma (MCL).
Both studies, co-led by researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) and at MD Anderson Cancer Center, were published in the Journal's June 19, 2013 online edition.
Chronic Lymphocytic Leukemia and Ibrutinib
Results from this phase Ib/II trial showed an overall response rate (complete and partial) of 71 percent. At 26 months the estimated progression-free survival rate was 75 percent and overall survival was 83 percent.
"Essentially all CLL patients respond well to ibrutinib, which lacks many of the side effects of chemotherapy and frequently produces long-lasting remissions even in patients with high-risk genetic lesions," says study co-leader John C. Byrd, MD, director of the division of hematology and a CLL specialist at the OSUCCC -- James.
CLL is the most common form of leukemia with an estimated 15,000 Americans diagnosed annually. It is a cancer of B cells, which are a major component of the immune system along with T cells. Ibrutinib (PCI-32765) is the first drug designed to target Bruton's tyrosine kinase, a protein essential for CLL-cell survival and proliferation. Ibrutinib kills malignant B cells but has little effect on healthy T cells -- unlike other CLL therapies. This leaves an important arm of the immune system largely intact, enabling patients to remain healthier during treatment.
The trial involved 85 relapsed CLL patients (median age, 66) who took ibrutinib once daily. Fifty-one patients received a 420 mg dose and 34 patients received an 840 mg dose. Long-term therapy was associated with modest side effects such as diarrhea, fatigue, and infection that usually resolved with no treatment delay.
Funding for the study was provided by Pharmacyclics, Inc.; the Leukemia and Lymphoma Society; D. Warren Brown Foundation; Mr. and Mrs. Michael Thomas; the Harry Mangurian Foundation; and the NIH/National Cancer Institute (grant CA140158 and CA095426).
Mantle Cell Lymphoma and Ibrutinib
Results from this phase II trial showed an overall response rate of 68 percent, with 21 percent of patient achieving a complete response and 47 percent achieving a partial response. Estimated overall survival was 58 percent at 18 months.
"This is remarkable because the last agent approved by the Food and Drug Administration for MCL had a 30 percent response rate," says senior author Kristie Blum, MD, associate professor of medicine, and head of the OSUCCC -- James lymphoma program. "This trial suggests that ibrutinib could significantly improve the landscape of therapy options for MCL."
MCL is a type of non-Hodgkin lymphoma, a malignancy that is expected to strike nearly 70,000 Americans in 2013. About 7 percent of those cases will be MCL, a cancer of white blood cells called B lymphocytes, or B cells. Currently, oncologists treat MCL using combination chemotherapy or intensive chemotherapy plus immunotherapy, followed by stem-cell transplantation.
The trial involved 111 patients with relapsed or refractory MCL who took ibrutinib. The trial was conducted at 18 sites. Participants had received one to five prior treatments, which could include the drug bortezomib, an agent sometimes used to treat MCL. The estimated median response duration was 17.5 months and estimated median progression-free survival was 14 months.
Funding for the study was provided by Pharmacyclics, Inc.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/RZ4UrFnANmM/130619195217.htm
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FAIRPORT, Mich. (AP) ? A wooden beam that has long been the focus of the search for a 17th century shipwreck in northern Lake Michigan was not attached to a buried vessel as searchers had suspected, but still may have come from the elusive Griffin or some other ship, archaeologists said Wednesday.
Shipwreck hunter Steve Libert discovered a 10.5-foot section of the timber jutting from the lake bed twelve years ago in an area where he was convinced that the Griffin, commanded by the French explorer Rene Robert Cavelier de la Salle, sank in 1679. French experts who inspected the beam in recent days said it appeared to be a bowsprit ? a spur or pole that extends from a vessel's stem ? that was hundreds of years old.
Crews have been digging since last week beside the timber, where sonar readings indicated that one or more objects that together exceeded 40 feet long were submerged in mud. Libert and other expedition leaders believed they might be the hull of the Griffin, and that the excavation would find a connection between it and the presumed bowsprit.
But on Tuesday, as a diver was widening the pit, the timber began wobbling. Archaeologists and leaders of Libert's Great Lakes Exploration Group decided to take it down instead of trying to stabilize it, fearing it was a safety risk. So the diver eased it to the lake bed after checking beneath and discovering that it wasn't attached to another object, but simply had been embedded in the tightly packed sediments.
Even though no other wreckage was found, project manager Ken Vrana said there's still a chance the ship is nearby. With the timber no longer in place, crews stepped up their dredging operation in hopes of reaching a hard surface that a probing device has indicated is 18 to 20 feet down.
"It could be that the ship is very close to this area, but it is impossible to say for sure at this point," said Michel L'Hour, director of France's Department of Underwater Archaeological Research and a shipwreck expert.
Members of the expedition team pointed to other hopeful signs: The bottom of the timber was cut at an angle suggesting it might have been fashioned to fit into another structure; and the timber's full length proved to be just over 19 feet, similar to that of bowsprits on other French vessels from La Salle's era. The upper end is tapered, and a series of fastening pegs are attached to the side.
After consulting by telephone with state archeologist Dean Anderson, the group planned to leave the timber in the lake for now ? wrapped in protective cloth and hidden to shield it from theft, vandalism or accidental damage from contact with objects such as boat anchors.
Putting it back where searchers found it wasn't an option because it might slide further into the hole. It might eventually be hauled to shore and put on display, but that would require expensive treatment to prevent deterioration.
"Any time you bring a water-logged item off the lake bottom, it would be a complicated and difficult process," Anderson told The Associated Press in a phone interview. "In this case, I don't think we know what this piece is. We would need a lot more information about it before anyone would consider bringing it up. Leaving it down there is a good solution."
Anderson's office has the ultimate say because the state asserts jurisdiction over Michigan's Great Lakes bottomlands ? including shipwrecks, although officials have acknowledged that if the Griffin is found, it will belong to France.
He said he wasn't unhappy that the beam was dislodged, even though a research proposal submitted by Great Lakes Exploration Group agreed to keep it stable.
"These sorts of plans are based on the best information you have at the time," Anderson said. Removing it from the sediment didn't appear to do any damage, he added.
Libert and the state battled for years in federal court over control of the suspected Griffin site before reaching a settlement in 2010. The Department of Natural Resources, which includes the state archaeologist's office, issued an excavation permit that expires Friday.
Source: http://news.yahoo.com/wooden-beam-could-detached-part-shipwreck-152523203.html
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The Wishlist feature is a part of Google Play that doesn't get much exposure. Added in the fall of 2012 during the first Play Store refresh, it's a handy tool to help you keep track of all the stuff you want from Google Play. Apps, books, movies, TV shows, magazines and music can all be added to your Wishlist, and while there is no way to share your list with friends and family just yet, it does put everything into one easy to manage spot on your phone or tablet.
Adding and removing items is easy, you'll find the Wishlist icon at the top of every item in Google Play. It's like a toggle switch, so if an item isn't on your list tapping will put it there, and if it is on your list a tap will remove it. To manage your list, the Google Play app menu has an entry for its page, and a tap takes you there. From your Wishlist page you can buy, rent, install or delete any item.
The Wishlist hasn't made its way to the web interface yet, so this is something you'll need to do from your phone or tablet. We have a feeling that's going to change when Google releases the new Play Store website, but for now know that you need an Android device to take advantage.
We've got a short tutorial after the break that will help it all make sense if you're not following. Have a watch, then grab your phone and start making that list!
Visit our Google Play mini-site for everything there is to know about Google Play
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Source: http://feedproxy.google.com/~r/androidcentral/~3/r6ivu2O-DcQ/story01.htm
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